Red Blossom
Safely Burn Fat*
- Evodia exhibits capsaicin’s characteristic anti-obese effects, without the subsequent gastrointestinal irritation or discomfort that often results from the ingestion of these hot foods. Capsaicin is the active compound in spicy foods. (1)
- Evodia causes heat loss and heat production, while also diffusing food energy. This subsequently prevents the accumulation of abdominal fat. A recent study demonstrats that when Evodia is fed to mice, supplemented at 0.03 % of the diet, the abdominal fat becomes much lower than in the control group. (1)
- Evodia studies have shown evidence of thermogenesis (the physiologic process of heat production in the body). (2)
- Evodia increases lipolytic activity which is the formation of free fatty acids from adipose tissue. This is the mechanism of metabolizing fat into heat energy (1)
Heart Function Support*
- Evodia helps to decrease blood pressure (anti-hypertensive). Decreases in diastolic blood pressure were more dramatic than systolic pressure, implying a vasodilatory effect. (6)
- Evodia assists in normalizing rhythmicity of the heartbeat (anti-arrhythmia).(7)
- A recent study also demonstrated that when Evodia was fed to mice on a high-fat diet in the form of an alcohol extract (.02%) for 21 days, total body weight, perivisceral (abdominal) fat, epididymal (testicular) fat, and total cholesterol, lipids, (fats) and triglycerides in the liver were significantly reduced as compared to the control group. (1)
- Evodia supports heart beat contractions and the heart’s pumping capacity. (8)
- Evodia aids in the prevention of cardiac anaphylactic injury associated with stimulation of calcitonin gene-related peptide (CGRP) release, which combats cardiac anaphylactic injury. (9)
- Evodia helps to increase cerebral blood flow (cerebrovascular health). (3)
Energy Boost*
- Evodia acts on the stomach and liver which then gernerates an energizing effect by normalizing digestion and improving the digestion of food.
- Evodia promotes oxygen, which cells require, to provide a continuous supply of energy and to constantly synthesize adenosine triphosphate (ATP—the fuel used within the cell to perform work). The more oxygen-enriched the body is, the more ATP each cell can produce.
Appetite Suppression Naturally*
- Evodia helps activate the hormone cholecystokinin (CCK), an appetite suppressing hormone released in the stomach wall, hence reducing cravings and food consumption. (11)
- Evodia encourages inhibition of gastric emptying and gastrointestinal transit. Longer gastric emptying durations result in prolonged feelings of fullness. (11)
(1) Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001 Oct; 67(7):628-33.
(2) Kobayashi et al (2001) notes increases in GDP (guanosine 5′-diphosphate) binding in brown adipose tissue mitochondria in rats.
(3) Pei-Hsuan Hung, Lie-Chwen Lin, Geui-Jane Wang, Chieh-Fu Chen, and Paulus S.Wang. Inhibitory Effect of Evodiamine on Aldosterone Release by Zona Glomerulosa Cells in Male Rats. Chinese J of Phys June 30; Vol 44: No 2, 2001.
(6) Chiou WF, Liao JF, Chen CF. Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa. J Nat Prod. 1996 Apr; 59(4):374-8.
(7) Loh SH, Lee AR, Huang WH, Lin CI.Br J Pharmacol. Ionic mechanisms responsible for the antiarrhythmic action of dehydroevodiamine in guinea-pig isolated cardiomyocytes. 1992 Jul; 106(3):517-23.
(8) Kobayashi Y, Hoshikuma K, Nakano Y, Yokoo Y, Kamiya T.The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors. Planta Med. 2001 Apr; 67(3):244-8.
(9) Rang WQ, Du YH, Hu CP, Ye F, Tan GS, Deng HW, Li YJ. Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis. Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar; 367(3):306-11.
(10) Yamahara J, Yamada T, Kitani T, Naiton Y, Fujimura H. Antianoxic action of Evodiamine, an alkaloid in Evodia rutaecarpa fruit. J Ethnopharmacol 1989; 27:185-192
(11) Wu CL, Hung CR, Chang FY, Lin LC, Pau KY, Wang PS. Effects of evodiamine on gastrointestinal motility in male rats. Eur J Pharmacol. 2002 Dec 20; 457(2-3): p. 169-176.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
